Growth Hormone Secretagogues (GHS)

Growth Hormone Secretagogues (GHS) are a class of peptides that stimulate the pituitary gland to release more HGH. They work through two main mechanisms: some mimic Growth Hormone-Releasing Hormone (GHRH), while others mimic ghrelin (the "hunger hormone"), which also potently stimulates HGH release. The most effective protocols often combine both types for a synergistic effect.

Key GHS Peptides

CJC-1295	A GHRH analog with a long half-life. Provides a sustained elevation of HGH levels. Often paired with Ipamorelin.
Ipamorelin	A selective ghrelin mimetic. Stimulates HGH release with minimal effect on cortisol or prolactin — considered one of the cleanest GHS peptides.
Sermorelin	A shorter GHRH analog. One of the most studied GHS peptides, often used in anti-aging and HGH deficiency protocols.
Tesamorelin	FDA-approved GHRH analog for HIV-associated lipodystrophy. Also used off-label for abdominal fat reduction and muscle preservation.
GHRP-6 / GHRP-2	Older ghrelin mimetics. Potent HGH releasers but cause significant increases in appetite and cortisol.

The combination of CJC-1295 and Ipamorelin is one of the most popular stacks in the peptide community because they work through complementary mechanisms — CJC-1295 amplifies the HGH pulse, while Ipamorelin triggers the pulse itself. Together, they produce a more robust and sustained HGH release than either peptide alone.